Endocrine Abstracts

Antithyroid drugs can cause hepatic dysfunction, from mild derangement to severe, fulminant failure. It is well known that propylthiouracil may cause fulminant liver failure yet we present an exceptionally rare case of this type of adverse drug reaction with carbimazole.A 75 year old woman presented to hospital with a fall and a two day history of jaundice. Six weeks earlier, she had been diagnosed with both congestive cardiac failure and G...

Antithyroid drugs can cause hepatic dysfunction, from mild derangement to severe, fulminant failure. It is well known that propylthiouracil may cause fulminant liver failure yet we present an exceptionally rare case of this type of adverse drug reaction with carbimazole.A 75 year old woman presented to hospital with a fall and a two day history of jaundice. Six weeks earlier, she had been diagnosed with both congestive cardiac failure and G...

A 43 year old hypertensive lady was referred to a surgical team at a tertiary oncology centre for consideration of completion thyroidectomy following removal of a nodule the histology of which had shown medullary thyroid carcinoma. She was reviewed in the cancer Multi-Disciplinary Team meeting; surgery was deferred until she had been reviewed in the endocrine clinic.There was no known family history of MTC or other endocrine abnormality; however the pati...

We report a case of two incidental lesions, a benign adrenal schwannoma and cerebral meningioma. There are no cases in the literature to link de-novo adrenal schwannoma and meningioma in patients. This case highlights the importance of multidisciplinary working to ensure expedited management in such cases.A 76 year old gentleman presented to ED with a seizure and a community-acquired pneumonia. Past medical history included atr...

We report a case of two incidental lesions, a benign adrenal schwannoma and cerebral meningioma. There are no cases in the literature to link de-novo adrenal schwannoma and meningioma in patients. This case highlights the importance of multidisciplinary working to ensure expedited management in such cases.A 76 year old gentleman presented to ED with a seizure and a community-acquired pneumonia. Past medical history included atr...

Multiple Endocrine Neoplasia is characterised by the occurrence of tumours involving two or more endocrine glands within a single patient. MEN are autosomal dominant disorders. Four forms have been described: MEN 1 due to menin mutations, MEN2 (previously MEN2A) due to mutations of a tyrosine kinase receptor encoded by the rearranged during transfection (RET) protoncogene, MEN3 (previously MEN2B) due to RET mutations and MEN4 due to cyc...

Multiple Endocrine Neoplasia is characterised by the occurrence of tumours involving two or more endocrine glands within a single patient. MEN are autosomal dominant disorders. Four forms have been described: MEN 1 due to menin mutations, MEN2 (previously MEN2A) due to mutations of a tyrosine kinase receptor encoded by the rearranged during transfection (RET) protoncogene, MEN3 (previously MEN2B) due to RET mutations and MEN4 due to cyc...

Case history: We describe a rare case of a 59-year-old woman, whose hypercortisolism was unmasked following transphenoidal surgery for Acromegaly. She presented to the Endocrine Clinic in 2006 with acromegalic features and MRI revealing a pituitary macroadenoma 20×18×18 mm. Repeat dynamic evaluation showed inadequate GH suppression (initially normal), raising the possibility of early rumbling Acromegaly. 0900 h serum cortisol was 287 nmol/l. She was started on Caberg...

Coexistence of Acromegaly with Cushing’s syndrome in the same individual is rare. We herein describe a case of a 59-year-old woman, whose hypercortisolism was unmasked following transphenoidal surgery for Acromegaly.She presented to the Endocrine Clinic in 2006 with acromegalic features and MRI revealing a pituitary macroadenoma 20×18×18 mm. Repeat dynamic evaluation showed inadequate GH suppression (initially normal), raising the possibil...

We report a rare case of a patient presenting with headaches and almost complete bilateral hemianopia during her third trimester of pregnancy. This lady presented with headaches and vomiting 2 years prior, with a pituitary MRI initially reporting an acute pituitary haemorrhage. This time, due to progression of her visual field defects, it was decided in a multidisciplinary meeting to perform a Caesarean section at 37 weeks and start Cabergoline post-operatively, as the patient...